LRRK2 in Parkinson's disease and dementia with Lewy bodies.

Xiongwei Zhu; Asim K. Babar; Sandra L. Siedlak; Qiwei Yang; Genta Ito; Takeshi Iwatsubo; Mark A. Smith; George Perry; Shu G. Chen

doi:10.1186/1750-1326-1-17

Abstract

1 min read

We conclude that LRRK2 is a component of Lewy bodies in both PD and DLB, and therefore plays an important role in the Lewy body formation and disease pathogenesis. Information on the cellular localization of LRRK2 under normal and pathological conditions will deepen our understanding of its functions and molecular pathways relevant to the progression of PD and related disorders.

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