Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

Tatsuya Saitoh; Naonobu Fujita; Myoung Ho Jang; Satoshi Uematsu; Bo‐Gie Yang; Takashi Satoh; Hiroko Omori; Takeshi Noda; Naoki Yamamoto; Masaaki Komatsu; Keiji Tanaka; Taro Kawai; Tohru Tsujimura; Osamu Takeuchi; Tamotsu Yoshimori; Akira Shizuo

doi:10.1038/nature07383

Related publications

Preprint2022

Author response: Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses

Mimmi L. E. Lundahl, Morgane Mitermite, Dylan G. Ryan, Sarah Case, Niamh C. Williams, Ming Yang, Roisin I. Lynch, Eimear Lagan, Filipa Lebre, Aoife L. Gorman, Bojan Stojkovic, Adrian P. Bracken, Christian Frezza, Frederick J. Sheedy, Eoin M. Scanlan, Luke O'neill, Stephen V. Gordon, Ed C. Lavelle

Article2013

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik, Eva M. Pålsson‐McDermott, Anne F. McGettrick, Gautam Goel, Christian Frezza, Nicholas J. Bernard, Beth Kelly, Niamh H. Foley, Liang Zheng, Agnès Gardet, Zhen Tong, S. S. Jany, Sinéad C. Corr, Moritz Haneklaus, Brian E. Caffrey, Kerry A. Pierce, Sarah R. Walmsley, Federico C. Beasley, Eoin P. Cummins, Victor Nizet, Moira K. B. Whyte, Cormac T. Taylor, Hening Lin,

Article2013

FIP200 regulates targeting of Atg16L1 to the isolation membrane

Taki Nishimura, Takeshi Kaizuka, Ken Cadwell, Mayurbhai H. Sahani, Tatsuya Saitoh, Akira Shizuo, Herbert W. Virgin, Noboru Mizushima

EMBO Reports

Article2010

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Seth L. Masters, Aisling Dunne, Shoba Subramanian, Rebecca L. Hull, Gillian M. Tannahill, Fiona A. Sharp, Christine Becker, Luigi Franchi, Eiji Yoshihara, Zhe Chen, N Mullooly, Lisa A. Mielke, James Harris, Rebecca C. Coll, Kingston H. G. Mills, K. Hun Mok, Philip Newsholme, Gabriel Nuñez, Junji Yodoi, Steven E. Kahn, Ed C. Lavelle, Luke O'neill

Nature Immunology

Article2017

Elucidation of control mechanism of type 2A protein phosphatase by autophagy

Nobuyuki Fujiwara, Syusaku Shibutani, Yusuke Sakai, Hiroshi Shima, Toshio Watanabe, Hiroko Oshima, Masanobu Oshima, Tatsuya Saitoh, Akira Shizuo, Hiroaki Nagano, Tathuya Usui, Takashi Ohama, Koichi Sato

The Japanese Biochemical Society/The Molecular Biology Society of Japan