Longitudinal evaluation of leukoaraiosis with whole brain ADC histograms

Mario Mascalchi; Marco Moretti; Riccardo Della Nave; Francesco Lolli; Carlo Tessa; Giovanna Carlucci; L. Bartolini; Giovanni Pracucci; Leonardo Pantoni; Massimo Filippi; Domenico Inzitari

doi:10.1212/wnl.59.6.938

Abstract

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FLAIR and diffusion-weighted MRI were obtained twice (mean interval 20 +/- 4 months) in 10 patients with leukoaraiosis. At follow-up, visual extension of leukoaraiosis was unchanged, whereas the median of whole brain apparent diffusion coefficient (WB-ADC) histogram was increased (p= 0.008) and brain volume index (BVI) was decreased (p = 0.006). WB-ADC histogram and BVI are sensitive to leukoaraiosis and might be considered for monitoring progression of the disease.

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