Longer illness duration is associated with greater individual variability in functional brain activity in Schizophrenia, but not bipolar disorder

Julia Gallucci; Edith Pomarol‐Clotet; Aristotle N. Voineskos; Amalia Guerrero‐Pedraza; Sílvia Alonso-Lana; Eduard Vieta; Raymond Salvador; Colin Hawco

doi:10.1016/j.nicl.2022.103269

Abstract

1 min read

An increase in variability was observed in the schizophrenia group related to illness duration, beyond the effects of normal aging, implying illness-related deterioration of cognitive networks. This has clinical implications for considering long-term trajectories in schizophrenia and progressive neural and cognitive decline which may be amiable to novel treatments.

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