Lipocalin 2 (LCN2)-deficient mice are more prone to hepatic steatosis: LCN2 and mitochondrial and peroxisomal integrity

Background: Lipocalin-2 (LCN2) or neutrophil gelatinase-associated lipocalin (NGAL) is a small secreted adipokine associated with transport of small hydrophobic molecules [1]. In the liver, it limits bacterial growth and modulates the inflammatory response by acting as a “help me” signal attracting circulating blood cells into the tissue [2]. We have previously demonstrated that LCN2 is involved in control of hepatic fat metabolism by regulating the expression of the intracellular lipid droplet protein PLIN5/O'X'PAT [3].