Lipid-Modulating Agents for Prevention or Treatment of COVID-19 in Randomized Trials
Preprint 2021 en
Authors
AT
Azita H. Talasaz
PS
Parham Sadeghipour
MA
Maryam Aghakouchakzadeh
Abstract
1 min read
Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation, endothelial activation, and multi-organ manifestations. Lipid modulating agents may be useful in treating patients with COVID-19. They may inhibit viral entry by lipid raft disruption or ameliorate the inflammatory response and endothelial activation. In addition, dyslipidemia with lower high-density lipoprotein cholesterol and higher triglycerides portends worse outcome in patients with COVID-19. Upon a systematic search, 40 RCTs with lipid modulating agents were identified, including 17 statin trials, 14 omega-3 fatty acids RCTs, 3 fibrates RCTs, 5 niacin RCTs, and 1 dalcetrapib RCT for management or prevention of COVID-19. This manuscript summarizes the ongoing or completed randomized controlled trials (RCTs) of lipid modulating agents in COVID-19 and the implications of these trials for patient management.
Azita H. Talasaz, Parham Sadeghipour, Hessam Kakavand, Maryam Aghakouchakzadeh, Elaheh Kordzadeh-Kermani, Benjamín Van Tassell, Azin Gheymati, Hamid Ariannejad, Seyed Hossein Hosseini, Sepehr Jamalkhani, Michelle Sholzberg, Manuel Monréal, David Jiménez, Gregory Piazza, Sahil A. Parikh, Ajay J. Kirtane, John W. Eikelboom, Jean M. Connors, Beverley J. Hunt, Stavros Konstantinides, Mary Cushman, Jeffrey I. Weitz, Gregg W. Stone, Harlan M. Krumholz, Professor Gregory Lip, Samuel Z. Goldhaber, Behnood Bikdeli
Luis Ortega‐Paz, Azita H. Talasaz, Parham Sadeghipour, Tatjana Potpara, Herbert D. Aronow, Luis Jara Palomares, Michelle Sholzberg, Dominick J. Angiolillo, Professor Gregory Lip, Behnood Bikdeli
Cathrine Axfors, Andreas M. Schmitt, Perrine Janiaud, Janneke van ’t Hooft, Sherief Abd‐Elsalam, Ehab Fawzy Abdo, Benjamin S. Abella, Javed Akram, Ravi K. Amaravadi, Derek Angus, Yaseen M. Arabi, Shehnoor Azhar, Lindsey R. Baden, Arthur W. Baker, Leïla Belkhir, Thomas Benfield, Marvin A. H. Berrevoets, Cheng‐Pin Chen, Tsung‐Chia Chen, Shu‐Hsing Cheng, Chien‐Yu Cheng, Wei‐Sheng Chung, Yehuda Z. Cohen,
Mahesh V. Madhavan, Behnood Bikdeli, Aakriti Gupta, David Jiménez, John Burton, Caroline Der‐Nigoghossian, Taylor Chuich, Shayan Nabavi Nouri, Isaac Dreyfus, Elissa Driggin, Sanjum S. Sethi, Kartik Sehgal, Saurav Chatterjee, Walter Ageno, Mohammad Madjid, Yutao Guo, Liang Tang, Yu Hu, Laurent Bertoletti, Jay Giri, Mary Cushman, I. Quéré, Evangelos Dimakakos, C. Michael Gibson,
Farhad Khimani, Adam J. Wolf, Braian Yoon, Amy Blancke, Coltin Gerhart, Dakota Endsley, Alleyna Dougherty, Anish Ray, Angelito F. Yango, Stuart D. Flynn, Professor Gregory Lip, Stevan A. Gonzalez, Mohanakrishnan Sathyamoorthy
Discussion(0)
No comments yet. Be the first to comment.