Lipid availability determines fate of skeletal progenitor cells via SOX9
Article 2020 en
Authors
VN
van Gastel N
SS
Steve Stegen
GE
Guy Eelen
Abstract
1 min read
In brief: In large fracture calluses, skeletal progenitors activate the chondrogenesis program, whereas in smaller calluses, direct osteogenesis is the preferred path. Here, the authors show that lipid availability determines whether skeletal stem cells repair a fracture through endochondral bone formation or direct ossification.
Nick van Gastel, Steve Stegen, Guy Eelen, Sandra Schoors, Aurélie Carlier, Veerle W. Daniëls, Ninib Baryawno, Dariusz Przybylski, Maarten Depypere, Pieter‐Jan Stiers, Dennis Lambrechts, Riet Van Looveren, Sophie Torrekens, Azeem Sharda, Patrizia Agostinis, Diether Lambrechts, Frederik Maes, Johan Swinnen, Liesbet Geris, Hans Van Oosterwyck, Bernard Thienpont, Peter Carmeliet, David T. Scadden, Geert Carmeliet
Nick van Gastel, Steve Stegen, Guy Eelen, Sandra Schoors, Aurélie Carlier, Veerle W. Daniëls, Maarten Depypere, Pieter‐Jan Stiers, Riet Van Looveren, Sophie Torrekens, Patrizia Agostinis, Frederik Maes, Johan Swinnen, Liesbet Geris, Hans Van Oosterwyck, Peter Carmeliet, David T. Scadden, Geert Carmeliet
Discussion(0)
No comments yet. Be the first to comment.