Linkage of DNA Methylation Quantitative Trait Loci to Human Cancer Risk
Article 2014 en
Authors
HH
Holger Heyn
SS
Sergi Sayols
CM
Cátia Moutinho
Abstract
1 min read
Epigenetic regulation and, in particular, DNA methylation have been linked to the underlying genetic sequence.DNA methylation quantitative trait loci (meQTL) have been identified through significant associations between the genetic and epigenetic codes in physiological and pathological contexts.We propose that interrogating the interplay between polymorphic alleles and DNA methylation is a powerful method for improving our interpretation of risk alleles identified in genome-wide association studies that otherwise lack mechanistic explanation.We integrated patient cancer risk genotype data and genome-scale DNA methylation profiles of 3,649 primary human tumors, representing 13 solid cancer types.We provide a comprehensive meQTL catalog containing DNA methylation associations for 21% of interrogated cancer risk polymorphisms.Differentially methylated loci harbor previously reported and as-yet-unidentified cancer genes.We suggest that such regulation at the DNA level can provide a considerable amount of new information about the biology of cancer-risk alleles.
Yaohua Yang, Lang Wu, Xiang Shu, Yingchang Lu, Xiao-Ou Shu, Qiuyin Cai, Alicia Beeghly‐Fadiel, Bingshan Li, Fei Ye, Andrew Berchuck, Hoda Anton‐Culver, Susana Banerjee, Javier Benı́tez, Line Bjørge, James D. Brenton, Ralf Bützow, Ian Campbell, Jenny Chang‐Claude, Kexin Chen, Linda S. Cook, Daniel W. Cramer, Anna DeFazio, Joe Dennis, Jennifer A. Doherty, Thilo Dörk, Diana Eccles, Digna Velez Edwards, Peter A. Fasching, Renée T. Fortner, Simon A. Gayther, Graham G. Giles, Rosalind Glasspool, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Holly R. Harris, Florian Heitz, Michelle A.T. Hildebrandt, Estrid Høgdall, Claus Høgdall, David G. Huntsman, Siddhartha Kar, Beth Y. Karlan, Linda E. Kelemen, Lambertus A. Kiemeney, Susanne K. Kjær, Anita Koushik, Diether Lambrechts, Nhu D. Le, Douglas A. Levine, Leon F.A.G. Massuger, Keitaro Matsuo, Taymaa May, Iain A. McNeish, Usha Menon, Francesmary Modugno, Álvaro N.A. Monteiro, Patricia G. Moorman, Kirsten B. Moysich, Roberta B. Ness, Heli Nevanlinna, Håkan Olsson, N. Charlotte Onland‐Moret, Sue K. Park, James Paul, Celeste Leigh Pearce, Tanja Pejović, Catherine M. Phelan, Malcolm C. Pike, Susan J. Ramus, Elio Riboli, Cristina Rodríguez‐Antona, Isabelle Romieu, Dale P. Sandler, Joellen M. Schildkraut, Veronica Wendy Setiawan, Shan Kang, Nadeem Siddiqui, Weiva Sieh, Meir J. Stampfer, Rebecca Sutphen, Anthony J. Swerdlow, Lukasz M. Szafron, Soo‐Hwang Teo, Shelley S. Tworoger, Jonathan P. Tyrer, Penelope M. Webb, Nicolas Wentzensen, Emily White, Walter C. Willett, Alicja Wolk, Yin Ling Woo, Anna H. Wu, Yan Li, Drakoulis Yannoukakos, Georgia Chenevix‐Trench, Thomas A. Sellers, Paul D.P. Pharoah, Wei Zheng, Jirong Long
Lang Wu, Yaohua Yang, Xingyi Guo, Xiao‐Ou Shu, Qiuyin Cai, Xiang Shu, Bingshan Li, Ran Tao, Chong Wu, Jason B. Nikas, Yanfa Sun, Jingjing Zhu, Monique J. Roobol, Graham G. Giles, Hermann Brenner, Esther M. John, Judith A. Clements, Eli Marie Grindedal, Jong Y. Park, Janet L. Stanford, Zsofia Kote‐Jarai, Christopher A. Haiman, Rosalind A. Eeles,
Discussion(0)
No comments yet. Be the first to comment.