Previous studies have shown that smoking cessation after a cardiac event reduces the risk of subsequent mortality in patients. The aim of this study was to describe the effect of smoking cessation in terms of prolonged life-years gained. The study sample comprised 856 patients who underwent percutaneous coronary intervention (PCI; balloon angioplasty) during 1980 to 1985. Patients were followed up for 30 years and smoking status at 1 year could be retrieved in 806 patients. The 27 patients who died within 1 year were excluded from the analysis. The median follow-up was 19.5 years (interquartile range 6.0 to 23.0). Cumulative 30-year survival rate was 29% in the group of patients who quit smoking and 14% in persistent smokers (p = 0.005). After adjustment for baseline characteristics at the time of PCI, smoking cessation remained an independent predictor of lesser mortality (adjusted hazard ratio 0.57, 95% confidence interval 0.46 to 0.71). The estimated life expectancy was 18.5 years in those who quit smoking and 16.4 years in the persistent smokers (p <0.0001). In conclusion, in patients with coronary heart disease who underwent PCI in the late 1980s, smoking cessation resulted in at least 2.1 life-years gained.
Katherine A. Epstein, Catherine M. Viscoli, J. David Spence, Lawrence H. Young, Silvio E. Inzucchi, Mark Gorman, Brett Gerstenhaber, Peter Guarino, Anand Dixit, Karen L. Furie, Walter N. Kernan, Christopher Bladin, Stephen C. Davis, Tissa Wijeratne, Christopher Levi, Mark Parsons, Amy Brodtmann, Steven Ng, John D. Archer, Candice Delcourt, Danilo Toni, Léo Berger, Jean‐Martin Boulanger, Richard Chan, J. David Spence, André Durocher, Ariane Mackey, Steve Verreault, Jeffrey Minuk, Andrew M. Penn, Ashfaq Shuaib, Robert Côté, Daniel Selchen, Neville Bayer, Margaret Sweet, Salim Malik, Grant Stotts, B. Griewing, Hassan Soda, Renate Weinhardt, Jörg Berrouschot, Anett Stoll, Otto W. Witte, Albrecht Günther, Ulf Bodechtel, Ulf Schminke, Carsten Hobohm, Andreas Hetzel, Johann Lambeck, Katja E. Wartenberg, Hagen B. Huttner, Ralf Dittrich, Darius G. Nabavi, Klaus Gröschel, Götz Thomalla, Michael Rosenkranz, Sebastian Jander, Andreas Meisel, Albert C. Ludolph, Katharina Althaus, Roman Huber, Matthias Lorenz, David Tanné, Oleg Merzlyak, Natan M. Bornstein, Gregory Telman, Yair Lampl, Jonathan Y. Streifler, Boaz Weller, Gal Ifergane, Y. Wirgin, Antonio Carolei, Danilo Toni, Paolo Stanzione, Giuseppe Micieli, Giancarlo Agnelli, Valeria Caso, Claudia Gandolfo, Giacomo P. Comi, Domenico Consoli, Maurizia Rasura, Vincenzo Di Lazzaro, Anand Dixit, Becky Jupp, Louise Shaw, Isam Salih, Bernard Esisi, Michael Power, W. David Strain, Salim Elyas, Dulka Manawadu, Lalit Kalra, Eoin O’Brien, Elizabeth A. Warburton, Kausik Chatterjee, David Hargroves, Adrian Blight, Barry Moynihan, Hugh S. Markus, M.J. Macleod
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Kuniaki Takahashi, Daniel J.F.M. Thuijs, Chao Gao, Masafumi Ono, David R. Holmes, Michael J. Mack, Marie‐Claude Morice, Friedrich‐Wilhelm Mohr, Nick Curzen, Piroze Davierwala, Milan Milojevic, Keith D. Dawkins, Joanna J. Wykrzykowska, Robbert J. de Winter, John W. McEvoy, Yoshinobu Onuma, Stuart J. Head, A. Pieter Kappetein, Patrick W. Serruys
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