The Alzheimer community lost Larry Sparks, one of its greatest innovators, on 14 May 2013.Larry was never shy about bringing new insights to discover and inform, whether cholinergic function, cholesterol, or copper.Through his insightful work on the link between heart and Alzheimer's diseases, Larry was the first to demonstrate an association between cholesterol and amyloid plaque deposition.He further showed that this association is mediated by copper metabolism, and was the first to test the efficacy of a cholesterollowering agent in the treatment of Alzheimer's disease.He was the author of over 100 research articles, many published in the most prestigious scientific journals, and his seminal contributions to the relationship between heart and Alzheimer's diseases were described in numerous national and scientific news outlets, including a cover article in Newsweek.His work was revolutionary in linking heart health to brain health-a new mainstream idea that is a direct result of Larry's perseverance and innovation.
Ora Bernard, Nam Sang Cheung, Chor Hui Vivien Koh, Matthew Whiteman, Q.-X. Li, Barry Halliwell, Andrew M. Jenner, Boon‐Seng Wong, Katrina Laughton, Markus R. Wenk, Colin L. Masters, Philip M. Beart
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