Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study — Stuart H. Ralston (2006) | RDL Network
Large-Scale Evidence for the Effect of the COLIA1 Sp1 Polymorphism on Osteoporosis Outcomes: The GENOMOS Study
Article 2006 en
Authors
SR
Stuart H. Ralston
AU
André G. Uitterlinden
MB
Maria Luisa Brandi
Abstract
1 min read
Allowing for the inevitable heterogeneity between participating teams, this study-which to our knowledge is the largest ever performed in the field of osteoporosis genetics for a single gene-demonstrates that the COLIA1 Sp1 polymorphism is associated with reduced BMD and could predispose to incident vertebral fractures in women, independent of BMD. The associations we observed were modest however, demonstrating the importance of conducting studies that are adequately powered to detect and quantify the effects of common genetic variants on complex diseases.
Stuart H. Ralston, André G. Uitterlinden, Maria Luisa Brandi, Susana Balcells, Bente Langdahl, P. Lips, Roman Lorenc, Barbara Obermayer‐Pietsch, Serena Scollen, Mariona Bustamante, Lise B. Husted, Alisoun H. Carey, Adolfo Díez‐Pérez, Alison M. Dunning, Alberto Falchetti, Elżbieta Karczmarewicz, Marcin Kruk, Johannes P.T.M. van Leeuwen, Joyce B. J. van Meurs, Jon Mangion, Fiona E. McGuigan, Leonardo Mellibovsky, Francesca Del Monte, Huibert A. P. Pols, J. Reeve, David M. Reid, Wilfried Renner, Fernando Rivadeneira, Natasja M. van Schoor, Rachael E. Sherlock, John P A Ioannidis
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