Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics

K. Meindl; Timo Schmiederer; Kathrin Schneider; Andreas Reicke; Diane Butz; Simone Keller; Hans Gühring; László Vértesy; Joachim Wink; Holger Hoffmann; Mark Brönstrup; In Memory: G.M. Sheldrick (1942–2025); Roderich D. Süßmuth

doi:10.1002/anie.200905773

Abstract

1 min read

A-maze-ing peptides: The structure of the novel lantibiotic labyrinthopeptin A2 (see picture) contains labionin—an unprecedented carbacyclic, posttranslationally modified amino acid. The identification of the biosynthetic gene cluster of labyrinthopeptins was also successful. Labyrinthopeptin A2 revealed a pronounced in vivo efficacy (attenuation of tactile allodynia) in a mouse model of neuropathic pain.

Related publications

Article2019

Non‐coding RNAs as Markers of Neuropathic Pain

Jenny L. Wilkerson, Jinmai Jiang, Jasmine S. Felix, Julie Bray, Lais Da Silva, Lance Richard McMahon, Thomas D Schmittgen

Article2018

The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis

Kate M. J. de Mattos-Shipley, Claudio Greco, David M. Heard, Gemma Hough, Nicholas P. Mulholland, Jean Louis Vincent, Jason Micklefield, Thomas J. Simpson, Christine L. Willis, Russell J. Cox, Andy M. Bailey

Article2004

Genome sequence of the deep-sea γ-proteobacterium <i>Idiomarina loihiensis</i> reveals amino acid fermentation as a source of carbon and energy

Shaobin Hou, Jimmy H. Saw, Kit Shan Lee, Tracey Freitas, Claude Bélisle, Yutaka Kawarabayasi, Stuart P. Donachie, Alla P. Pikina, Michael Y. Galperin, Eugene V Koonin, Kira S. Makarova, Marina V. Omelchenko, Alexander V. Sorokin, Yuri I. Wolf, Qing X. Li, Young Soo Keum, Sonia Campbell, Judith R. Denery, Shin‐Ichi Aizawa, Satoshi Shibata, Alexander Malahoff, M. Shahid Alam

Article2003

Inhibition of Human Immunodeficiency Virus by a New Class of Pyridine Oxide Derivatives

Miguel Stevens, Christophe Pannecouque, De Clercq Erik, Jan Balzarini

Article2000

Poly(alkylacetylenes): a new class of highly luminescent polyacetylenes

Yuan Ming Huang, Jacky W. Y. Lam, Kevin Ka Leung Cheuk, Weikun Ge, Ben Zhong Tang