Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills; Dylan G. Ryan; Hiran A. Prag; Dina Dikovskaya; Deepthi Menon; Zbigniew Zasłona; Mark P. Jedrychowski; Ana S.H. Costa; Maureen Higgins; Emily Hams; John Szpyt; Marah C. Runtsch; Martin S. King; Joanna F. McGouran; Román Fischer; Benedikt M. Kessler; Anne F. McGettrick; Mark Hughes; Richard G. Carroll; Lee M. Booty; Elena V. Knatko; Paul J. Meakin; Michael L.J. Ashford; Louise K. Modis; Gino Brunori; Daniel C. Sévin; Padraic G. Fallon; Stuart T. Caldwell; Edmund R.S. Kunji; Edward T. Chouchani; Christian Frezza; Albena T. Dinkova‐Kostova; Richard C. Hartley; Michael P. Murphy; Luke O'neill

doi:10.1038/nature25986

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