Isolation and Structure Determination of Daigremontianin, a Novel Bufadienolide from<i>Kalanchoe daigremontiana</i>

Two toxic principles of Kalanchoe daigremontiana were isolated and structurally elucidated as bufadienolides with an unusual substitution pattern. Daigremontianin, a novel compound, and bersaldegenin-1,3,5-orthoacetate which was also found in Kalanchoe tubiflora Hamet, show a pronounced sedative, positive inotropic and CNS-activity.