Is In Vivo Nuclear Magnetic Resonance Spectroscopy Currently a Quantitative Method for Whole-body Carbohydrate Metabolism? — Elizabeth A. Murphy (2009) | RDL Network
In vivo nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for noninvasive metabolic research. NMR studies of tissue glycogen metabolism and glucose utilization have generated results with major implications for normal glucose homeostasis and the pathophysiology of type 2 diabetes mellitus. A key question for clinicians and physiologists reading these highly technical studies is: How accurate for whole-body carbohydrate metabolism is NMR spectroscopy? We review this topic and discuss technical, metabolic, and interpretive factors that may limit quantitative accuracy of this modality. We conclude that seeing is not yet believing regarding in vivo NMR spectroscopy; there are still important limitations to quantification of whole-body carbohydrate metabolism.
Muhammad Rameez Chatni, Jun Xia, Rebecca Sohn, Konstantin Maslov, Zijian Guo, Yu Shrike Zhang, Kun Wang, Younan Xia, Mark A. Anastasio, Jeffrey M. Arbeit, Lihong V. Wang
Carine Beysen, Elizabeth J. Murphy, Tracey McLaughlin, Timothy Riiff, Cindy Lamendola, Holly Turner, Mohamad Awada, Scott Turner, Gerald M. Reaven, Marc Hellerstein
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