Involvement of Heat Shock Protein A4/Apg-2 in Refractory Inflammatory Bowel Disease
Article 2014 en
Authors
TA
Teppei Adachi
TS
Toshiharu Sakurai
HK
Hiroshi Kashida
Abstract
1 min read
Upregulation of Bcl-2 and IL-17 by HSPA4 would control apoptosis of inflammatory cells and immune response in the gut, which might develop treatment resistance in IBD. HSPA4 and Bmi1 would be a useful biomarker for refractory clinical course and a promising approach for a therapeutic strategy in patients with IBD.
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