Intrinsic Frequencies of Carotid Pressure Waveforms Predict Heart Failure Events

Intrinsic frequencies (IFs) derived from arterial waveforms are associated with cardiovascular performance, aging, and prevalent cardiovascular disease (CVD). However, prognostic value of these novel measures is unknown. We hypothesized that IFs are associated with incident CVD risk. Our sample was drawn from the Framingham Heart Study Original, Offspring, and Third Generation Cohorts and included participants free of CVD at baseline (N=4700; mean age 52 years, 55% women). We extracted 2 dominant frequencies directly from a series of carotid pressure waves: the IF of the coupled heart and vascular system during systole (ω₁) and the IF of the decoupled vasculature during diastole (ω₂). Total frequency variation (Δω) was defined as the difference between ω₁ and ω₂. We used Cox proportional hazards regression models to relate IFs to incident CVD events during a mean follow-up of 10.6 years. In multivariable models adjusted for CVD risk factors, higher ω₁ (hazard ratio [HR], 1.14 [95% CI], 1.03-1.26]; <i>P</i>=0.01) and Δω (HR, 1.16 [95% CI, 1.03-1.30]; <i>P</i>=0.02) but lower ω₂ (HR, 0.87 [95% CI, 0.77-0.99]; <i>P</i>=0.03) were associated with higher risk for incident composite CVD events. In similarly adjusted models, higher ω₁ (HR, 1.23 [95% CI, 1.07-1.42]; <i>P</i>=0.004) and Δω (HR, 1.26 [95% CI, 1.05-1.50]; <i>P</i>=0.01) but lower ω₂ (HR, 0.81 [95% CI, 0.66-0.99]; <i>P</i>=0.04) were associated with higher risk for incident heart failure. IFs were not significantly associated with incident myocardial infarction or stroke. Novel IFs may represent valuable markers of heart failure risk in the community.