Intrinsic Damage to the Cerebellar Peduncles Is Associated to Multiple Sclerosis Clinical Disability (P06.114)

OBJECTIVE: To apply a voxel-wise analysis to metrics from diffusion tensor (DT) MRI tractography and T2 lesions of the middle (M) and superior (S) cerebellar peduncles (CP) to quantify their structural damage in multiple sclerosis (MS) patients, and to assess the relationship between CP damage vs. global clinical disability, impairment of cerebellar (C) and brainstem (B) functional systems (FS) and ambulation.