Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity

Clément Anfray; Francesco Mainini; Elisabeth Digifico; Akihiro Maeda; Marina Sironi; Marco Erreni; Achille Anselmo; Aldo Ummarino; Sara Gandoy; Francisco Expósito; Miriam Redrado; Diego Serrano; Alfonso Calvo; Marvin Martens; Susana B. Bravo; Alberto Mantovani; Paola Allavena; Fernando Torres

doi:10.1136/jitc-2021-002408

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Alberto Mantovani

Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity

Article 2021 en

Authors

CA
Clément Anfray
FM
Francesco Mainini
ED
Elisabeth Digifico

Abstract

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These findings demonstrate the antitumor immune responses mediated by macrophage activation on local administration of poly(I:C)+R848 combination and support the intratumoral application of this therapy to patients with solid tumors in the clinic.

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Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor‐conditioned macrophages

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Akihiro Maeda, Elisabeth Digifico, Andon FT, Alberto Mantovani, Paola Allavena

Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity

Abstract

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Related publications

Dataset related to article "Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity "

Dataset related to article "Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity "

Abstract 5140: Combined administration of poly(I:C) and resiquimod triggers effective antitumoral response in mouse models of pancreatic adenocarcinoma

Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor‐conditioned macrophages

Dataset related to article "Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages."