Intratumoral CD16+ Macrophages Are Associated with Clinical Outcomes of Patients with Metastatic Melanoma Treated with Combination Anti-PD-1 and Anti-CTLA-4 Therapy — Hansol Lee (2023) | RDL Network
Intratumoral CD16+ Macrophages Are Associated with Clinical Outcomes of Patients with Metastatic Melanoma Treated with Combination Anti-PD-1 and Anti-CTLA-4 Therapy
Letter 2023 en
Authors
HL
Hansol Lee
AF
Angela L. Ferguson
CQ
Camelia Quek
Abstract
1 min read
Our data demonstrate that tumor microenvironments enriched with CD16+ macrophages are favorable for response to combination anti-PD-1 and anti-CTLA-4 therapy but not anti-PD-1 monotherapy. These data provides a potential biomarker of response for combination immunotherapies in patients with metastatic melanoma. See related commentary by Smithy and Luke, p. 2345.
Hansol Lee, Angela L. Ferguson, Camelia Quek, Ismael A. Vergara, Inês Pires da Silva, Ruth Allen, Tuba N. Gide, Jordan W. Conway, Lambros T. Koufariotis, Nicholas K. Hayward, Nicola Waddell, Matteo S. Carlino, Alexander M. Menzies, Robyn P.M. Saw, Elena Shklovskaya, Helen Rizos, Serigne Lo, Richard A Scolyer, Georgina V. Long, Umaimainthan Palendira, James S. Wilmott
Hansol Lee, Angela L. Ferguson, Camelia Quek, Ismael A. Vergara, Inês Pires da Silva, Ruth Allen, Tuba N. Gide, Jordan W. Conway, Lambros T. Koufariotis, Nicholas K. Hayward, Nicola Waddell, Matteo S. Carlino, Alexander M. Menzies, Robyn P.M. Saw, Elena Shklovskaya, Helen Rizos, Serigne Lo, Richard A Scolyer, Georgina V. Long, Umaimainthan Palendira,
Jarem Edwards, Inês Pires da Silva, Angela L. Ferguson, Peter A. Johansson, Jordan W. Conway, Grace H. Attrill, Robyn P.M. Saw, John F. Thompson, Alexander M. Menzies, Umaimainthan Palendira, Georgina V. Long, Richard A Scolyer, James S. Wilmott
Tuba N. Gide, Elizabeth C. Paver, Zarwa Yaseen, Nigel Maher, Nurudeen A. Adegoke, Alexander M. Menzies, Inês Pires da Silva, James S. Wilmott, Georgina V. Long, Richard A Scolyer
Tuba N. Gide, Camelia Quek, Jason Madore, Alexander M. Menzies, Rebecca Dent, Matteo S. Carlino, Alex Guminski, Robyn P.M. Saw, John F. Thompson, James S. Wilmott, Richard A Scolyer, Georgina V. Long
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