Innovative Technique for the Preparation of Porous Bilayer Hydroxyapatite/Chitosan Scaffolds for Osteochondral Applications — Joaquím M. Oliveira (2006) | RDL Network
Innovative Technique for the Preparation of Porous Bilayer Hydroxyapatite/Chitosan Scaffolds for Osteochondral Applications
Article 2006 en
Authors
JO
Joaquím M. Oliveira
SS
Simone S. Silva
JM
João F. Mano
Abstract
1 min read
In this study, it is shown that it is possible to develop 3D-porous bilayer hydroxyapatite/chitosan scaffolds by means of combining a sintering and a freeze-drying technique. Scanning electron microscopy (SEM/EDS) studies revealed that the scaffolds possess a well-defined orientation and anisotropic porosity, with pore size ranging between 50-350 µm. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) patterns evidenced the formation of crystalline hydroxyapatite. Moreover, the compression tests revealed that these scaffolds have adequate mechanical properties for being used in tissue engineering of osteochondral defects.
Joaquím M. Oliveira, Márcia T. Rodrigues, Simone S. Silva, Patrícia B. Malafaya, Manuela E. Gomes, Carlos Viegas, Isabel R. Dias, Jorge Manuel Teixeira de Azevedo, João F. Mano, Rui L Reis
Lya Piaia, Simone S. Silva, Emanuel M. Fernandes, Joana M. Gomes, Albina R. Franco, Isabel B. Leonor, Márcio C. Fredel, Gean Vitor Salmoria, Dachamir Hotza, Rui L Reis
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