Inhibitory Activities of Three Classes of Acyclic Nucleoside Phosphonates against Murine Polyomavirus and Primate Simian Virus 40 Strains — Ilya Lebeau (2007) | RDL Network
Inhibitory Activities of Three Classes of Acyclic Nucleoside Phosphonates against Murine Polyomavirus and Primate Simian Virus 40 Strains
Article 2007 en
Authors
IL
Ilya Lebeau
GA
Graciela Andreï
MK
Marcela Krečmerová
Abstract
1 min read
Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine (DAPy) derivatives, and (iii) a new class of HPMP derivatives containing a 5-azacytosine moiety. The last class showed the highest activities and selectivities against both polyomaviruses.
Sophie Duraffour, Robert Snoeck, Marcela Krečmerová, Joost van den Oord, Rita De Vos, Antonı́n Holý, Jean‐Marc Crance, Daniel Garín, De Clercq Erik, Graciela Andreï
De Clercq Erik, Graciela Andreï, Jan Balzarini, Pieter Leyssen, Lieve Naesens, Johan Neyts, Christophe Pannecouque, Robert Snoeck, C. Ying, Dana Hocková, Antonı́n Holý
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