Influence of multidrug efflux systems on methylene blue-mediated photodynamic inactivation of Candida albicans
Article 2011 en
Authors
RP
Renato Araújo Prates
IK
Ilka Tiemy Kato
MR
Martha S. Ribeiro
Abstract
1 min read
The ABC pumps are directly implicated in MB efflux from the cell cytoplasm. Both the influx and efflux of MB may be regulated by MFS systems, and blocking this gate before incubation with MB can decrease the uptake and APDI effects. An ABC inhibitor could be usefully combined with MB APDI for treating C. albicans infections.
Ilka Tiemy Kato, Renato Araújo Prates, Caetano P. Sabino, Beth Burgwyn Fuchs, George P. Tegos, Eleftherios Mylonakis, Michael R Hamblin, Martha S. Ribeiro
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