Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis

Charles J. Fisher; Steven M. Opal; Jean-François Dhainaut; Sue Stephens; Janice L. Zimmerman; Peter Nightingale; S. Harris; Roland M.H. Schein; Edward A. Panacek; Jean Louis Vincent; Garrett E. Foulke; Edward Warren; CHRIS GARRARD; Gilbert Park; Mark Bodmer; Jonathan Cohen; CEES VAN DER LINDEN; Alan S. Cross; Jerald Sadoff

doi:10.1097/00003246-199303000-00006

Abstract

1 min read

The murine anti-TNF-alpha monoclonal antibody CB0006 has proven to be safe in this clinical trial and may prove to be useful in septic patients with increased circulating TNF concentrations. Further studies are needed to determine efficacy and the ultimate clinical utility of this immunotherapeutic agent in sepsis.

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