Индекс полярности фармакологических препаратов, используемых для профилактической терапии биполярного расстройства

Over one half of bipolar patients have been reported to be more prone to either depressive or manic relapses. This study aimed to defi ne profi les of drugs used for maintenance treatment of bipolar disorder (BD) by the means of Polarity Index. Polarity Index is a new metric indicating the relative antimanic versus antidepressive preventive effi cacy of drugs. Polarity Index was retrieved by calculating Number Needed to Treat (NNT) for prevention of depression and NNT for prevention of mania ratio, as emerging from the results of randomized placebo-controlled trials. Included trials were randomized and double blind, with a minimal duration of 24 weeks. Polarity Index value above 1.0 indicates a relative greater antimanic prophylactic effi cacy, number below 1.0 a relative greater antidepressive effi cacy. The Polarity Index for the drugs used in maintenance therapy for bipolar disorder was 12.09 for risperidone, 4.38 for aripiprazole, 3.91 for ziprasidone, 2.98 for olanzapine, 1.39 for lithium, 1.14 for quetiapine, and 0.40 for lamotrigine. The polarity index provides a measure of how much antidepressant versus antimanic a drug is in bipolar disorder prophylaxis, and may guide the choice of maintenance therapy in bipolar patients.