IN VITRO CYTOTOXIC ACTIVITY OF EXTRACTS OF MARCHANTIA CONVOLUTA ON HUMAN LIVER AND LUNG CANCER CELL LINES

The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to test cytotoxicity of the extracts from Marchantia convoluta against two human cancer cell lines (H1299 and HepG2). Low concentrations of the ethyl acetate extract had toxic effects on HepG2 cells and inhibited H1299 cells at higher concentration. Inhibition of proliferation and induction of cell death were in a concentration-dependent. However, the petroleum ether and n-butanol extracts of Marchantia convoluta showed no cytotoxic activity.