Impact of changing the threshold of statistical significance to P lower than 0.005 on recommended medical interventions

The aim of the present work is to assess the extent to which comparisons of interventions for active treatment versus no treatment from Cochrane meta-analyses in various fields of medicine that report statistically significant results would have been interpreted differently (“suggestive” rather than “statistically significant”) if the p-value threshold was shifted from the 0.05 routine threshold for claiming success to .005.