IMMUNOMODULATION BY INTRATHYMIC INJECTION OF DONOR LEUKOCYTES IN RHESUS MONKEYS1

Margreet Jonker; Yvon van den Hout; Riet Noort; Minke F. J. Versteeg-van der Voort Maarschalk; Frans H.J. Claas; Fokko J. vd Woude; Daan A M J Hollander; Norberto Perico; Giuseppe Remuzzi

doi:10.1097/00007890-200110270-00017

Abstract

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Donor cell pretreatment alters the subsequent response to an allogeneic skin graft in monkeys and is dependent on the route of donor cell administration. This is also reflected in the alloantibody response and the in vitro cellular reactivity. Intrathymic administration of donor cells does not lead to prolonged skin graft acceptance.

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