Immune-mediated adverse events and overall survival with tremelimumab plus durvalumab and durvalumab monotherapy in unresectable HCC: HIMALAYA phase III randomized clinical trial — George Lau (2025) | RDL Network
Immune-mediated adverse events and overall survival with tremelimumab plus durvalumab and durvalumab monotherapy in unresectable HCC: HIMALAYA phase III randomized clinical trial
Article 2025 en
Authors
GL
George Lau
BS
Bruno Sangro
AC
Ann‐Lii Cheng
Abstract
1 min read
Participants who experienced imAEs with STRIDE had a numerical improvement in OS versus those who did not, which was not observed for durvalumab. Long-term OS with STRIDE was observed regardless of imAEs. Most imAEs were low grade, manageable, and occurred in the first 3 months after treatment initiation. Results continue to support the benefits of STRIDE in a diverse population that reflects unresectable HCC globally.
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George Lau, Ghassan K. Abou‐Alfa, Ann‐Lii Cheng, Wattana Sukeepaisarnjaroen, Tu Van Dao, Yoon‐Koo Kang, C. Satheesh, Masatoshi Kudo, Bruno Sangro, Robin Kate Kelley, Junji Furuse, Joong‐Won Park, Patrapim Sunpaweravong, Angelica Fasolo, Thomas Yau, Tomokazu Kawaoka, Sérgio Jobim Azevedo, María Reig, Éric Assenat, Mark Yarchoan, Aiwu Ruth He, Mallory Makowsky,
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Marie‐Luise Berres, Stephen L. Chan, Masatoshi Kudo, Bruno Sangro, Robin Kate Kelley, Junji Furuse, Joong‐Won Park, Patrapim Sunpaweravong, Angelica Fasolo, Thomas Yau, Tomokazu Kawaoka, Ann-Li Cheng, Sérgio Santos de Azevêdo, María Reig, Éric Assenat, Mark Yarchoan, Aiwu Ruth He, Mallory Makowsky, Di Ran, Alejandra Negro, Ghassan K. Abou‐Alfa
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