Immune Checkpoint Inhibitors for Child-Pugh Class B Advanced Hepatocellular Carcinoma

Enrui Xie; Yee Hui Yeo; Bernhard Scheiner; Yue Zhang; Atsushi Hiraoka; Xinxing Tantai; Petros Fessas; Tiago B. R. Castro; Antonio D’Alessio; Claudia Angela Maria Fulgenzi; Shuo Xu; Hong‐Ming Tsai; Swetha Kambhampati; Wenjun Wang; Bridget P. Keenan; Xu Gao; Zixuan Xing; Matthias Pinter; Yih‐Jyh Lin; Zhanjun Guo; Arndt Vogel; Takaaki Tanaka; Hsin‐Yu Kuo; Robin Kate Kelley; Masatoshi Kudo; Ju Dong Yang; David J. Pinato; Fanpu Ji

doi:10.1001/jamaoncol.2023.3284

Abstract

1 min read

The findings of this systematic review and meta-analysis suggest that although the safety of ICI treatment was comparable between patients with HCC with vs without advanced liver disease and the treatment resulted in a significant number of radiologic responses, survival outcomes are still inferior in patients with worse liver function. More study is needed to determine the effectiveness of ICI treatment in this population.

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