CycloSal-2′-ara (ribo)-fluoro-2′,3′-dideoxyadenosine Monophosphates—An Effort to Solve the Structure-Activity Relationship of 2′-Fluoro-dda

Chris Meier; Tina Knispel; Víctor E. Márquez; De Clercq Erik; Jan Balzarini

doi:10.1080/15257779908041598

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CycloSal-2′-ara (ribo)-fluoro-2′,3′-dideoxyadenosine Monophosphates—An Effort to Solve the Structure-Activity Relationship of 2′-Fluoro-dda

Article 1999 en

Abstract

1 min read

Novel lipophilic cycloSal-triesters 3 and 4 from the ara- and ribo-configurated 2'-fluorinated ddAs 1 and 2, respectively, were prepared. The title compounds 3 and 4 delivered the corresponding monophosphates and thus, increasing the bioactivity or convert a formerly inactive compound into a RT inhibitor.

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<i>Cyclo</i>Sal-2′-<i>ara (ribo)</i>-fluoro-2′,3′-dideoxyadenosine Monophosphates—An Effort to Solve the Structure-Activity Relationship of 2′-Fluoro-dda

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