Hypoxia-Inducible Factor 1 Regulates Vascular Endothelial Growth Factor Expression in Human Pancreatic Cancer

Peter Büchler; Howard A. Reber; Manuela C. Büchler; Shailesh Shrinkante; Markus W. Büchler; Helmut Frieß; Gregg L. Friedman; O. Joe Hines

doi:10.1097/00006676-200301000-00010

Abstract

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We conclude that HIF-1 is the regulatory link between tumor hypoxia and VEGF production in pancreatic cancer, thus establishing a biochemical pathway between tumor hypoxia and neoangiogenesis in this highly aggressive neoplasm.

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