Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs

Jian Wang; Xin Fu; Kai Yang; Jiang Qian; Yuqin Chen; Jing Jia; Xin Duan; Elizabeth W. Wang; Jianxing He; Pixin Ran; Nanshan Zhong; Gregg L. Friedman; Wenju Lu

doi:10.1093/cvr/cvv122

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Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs

Article 2015 en

Abstract

1 min read

BMP4 acts downstream of HIF-1 and mediates hypoxia-induced up-regulation of TRPC, leading to increased basal [Ca(2+)]i in PASMCs, promoting CHPH pathogenesis.

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