Hypoxia and Hypoxia-Inducible Factors in Lymphedema
Article 2022 en
Authors
XJ
Xinguo Jiang
WT
Wen Tian
DK
Dong-Eon Kim
Abstract
1 min read
Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease. Hypoxia is a recognized feature of inflammation, obesity, and fibrosis. Understanding hypoxia-regulated pathways in lymphedema may provide new insights into the pathobiology of this chronic disorder and help develop new medicinal treatments.
Xinguo Jiang, Wen Tian, Eric J. Granucci, Allen B. Tu, Dong-Eon Kim, Petra Dahms, Shravani Pasupneti, Gongyong Peng, Yesl Kim, Amber H. Lim, F. Hernán Espinoza, Matthew T. Cribb, J. Brandon Dixon, Stanley G. Rockson, Gregg L. Friedman, Mark R. Nicolls
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