Human dermal fibroblasts, keratinocytes and adipose stem cells behaviour on patterned electrospun nanofiber meshes

Natural extracellular Matrix (ECM) creates a unique cellular microenvironment. It acts as a support to organize cells in tissues, maintains their structure and works also as a reservoir for cytokines, thus controlling cell growth and differentiation. A well-defined biomaterial surface topography is believed to be adequate to mimic native ECM for guiding cell growth or tissue regeneration. This structure can be achieved by using an electrospinning technique, which allows producing a non-woven nanofibrous structure with topographic features mimicking the natural ECM. [...]