How a Modification (8‐Aza‐3‐deaza‐2′‐deoxyguanosine) Influences the Quadruplex Structure of Hotoda's 6‐Mer TGGGAG with 5′‐ and 3′‐End Modifications

Suzana Jakša; Bogdan Kralj; Christophe Pannecouque; Jan Balzarini; De Clercq Erik; J. Kobe

doi:10.1081/ncn-120027819

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How a Modification (8‐Aza‐3‐deaza‐2′‐deoxyguanosine) Influences the Quadruplex Structure of Hotoda's 6‐Mer TGGGAG with 5′‐ and 3′‐End Modifications

Article 2004 en

Authors

SJ
Suzana Jakša
BK
Bogdan Kralj
CP
Christophe Pannecouque

Abstract

1 min read

We have synthesized a modified 6-mer using Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications as a template. We have replaced from one to all four 2'-deoxyguanosines by 8-aza-3-deaza-2'-deoxyguanosine (c3z8dG, 1) in order to investigate the anti-HIV structure activity relationship (SAR). ODN 4 (TGGG*AG) is the only one that exhibits a moderate anti-HIV-1 activity.

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How a Modification (8‐Aza‐3‐deaza‐2′‐deoxyguanosine) Influences the Quadruplex Structure of Hotoda's 6‐Mer TGGGAG with 5′‐ and 3′‐End Modifications

Abstract

Discussion(0)

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