Depression is a serious psychological disorder that affects a significant population. We investigated the antidepressant activities of four pyridazinone derivatives that contain the hydrazide moiety using the forced swimming test (FST). The compounds tested exhibited good antidepressant activity compared to duloxetine. The most promising compound was compound 2, which reduced the duration of immobility during FST. The toxic effects of the four compounds on the histomorphology of the liver and stomach tissue also was evaluated.
Jinnat Rahman, Abu Montakim Tareq, Md. Mohotasin Hossain, Shahenur Alam Sakib, Mohammad Nazmul Islam, Md. Hazrat Ali, A Uddin, Muminul Hoque, Shamima Nasrin, Talha Bin Emran, Raffaele Capasso, A.S.M. Ali Reza, Jesus Simal Gandara
Marta Kubera, Agnieszka Basta–Kaim, Bogusława Budziszewska, Zofia Rogóż, G Skuza, Monika Leśkiewicz, Magdalena Tetich, L Jaworska-Feil, Michael Maes, Władysław Lasoń
Israt Jahan, Marzia Rahman Tona, Sanjida Sharmin, Mohammed Aktar Sayeed, Fatamatuz Zuhura Tania, Arkajyoti Paul, Md. Nazim Uddin Chy, Ahmed Rakib, Talha Bin Emran, Jesus Simal Gandara
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