Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly

Jörg Votteler; Liane Neumann; Sabine Hahn; Friedrich Hahn; Pia Rauch; Kerstin Schmidt; Nicole Studtrucker; Sara M. Ø. Solbak; Torgils Fossen; Peter Henklein; David E. Ott; Gudrun Holland; Norbert Bannert; Ulrich Sigmar Schubert

doi:10.1186/1742-4690-8-11

Abstract

1 min read

Overall, these data support a so far unrecognized function of p6 mediated by Ser-40 that occurs independently of the L-domain function, but selectively affects CA maturation and virus core formation, and consequently the infectivity of released virions.

Related publications

Article2014

Mutation of the Highly Conserved Ser-40 of the HIV-1 p6 Gag Protein to Phe Causes the Formation of a Hydrophobic Patch, Enhances Membrane Association, and Polyubiquitination of Gag

Friedrich Hahn, Christian Setz, Melanie Friedrich, Pia Rauch, Sara M. Ø. Solbak, Nils Åge Frøystein, Petra Henklein, Jörg Votteler, Torgils Fossen, Ulrich Sigmar Schubert

Article2000

Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2

Ulrich Sigmar Schubert, David E. Ott, Elena Chertova, Reinhold Welker, Uwe Tessmer, Michael F. Princiotta, Jack R. Bennink, Hans‐Georg Kräusslich, Jonathan W. Yewdell

Article2016

Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag

Melanie Friedrich, Christian Setz, Friedrich Hahn, Alina Matthaei, Kirsten Fraedrich, Pia Rauch, Petra Henklein, Maximilian Traxdorf, Torgils Fossen, Ulrich Sigmar Schubert

Article2017

Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner

Friedrich Hahn, Adrian Schmalen, Christian Setz, Melanie Friedrich, Stefan Schlößer, Julia Kölle, Robert Spranger, Pia Rauch, Kirsten Fraedrich, Tatjana Reif, Julia Karius-Fischer, Ashok Balasubramanyam, Petra Henklein, Torgils Fossen, Ulrich Sigmar Schubert

Article2000

Human Immunodeficiency Virus Type 1 Vpr Protein Is Incorporated into the Virion in Significantly Smaller Amounts than Gag and Is Phosphorylated in Infected Cells

Bárbara Müller, Uwe Tessmer, Ulrich Sigmar Schubert, Hans‐Georg Kräusslich