Highly Active Heterogeneous Palladium Nanoparticle Catalysts for Homogeneous Electrophilic Reactions in Solution and the Utilization of a Continuous Flow Reactor

A highly active heterogeneous Pd-nanoparticle catalyst for the intramolecular addition of phenols to alkynes was developed and employed in a continuous flow reaction system. Running the reaction in flow mode revealed reaction kinetics, such as the activation energy and catalyst deactivation, and provides many potential practical advantages.