Within two months of treatment for falciparum malaria, Plasmodium vivaxinfections developed in 58 (33%) of 174 patients who had received a quinine or quinidine regimen and in 46 (32%) of 145 patients who had received mefloquine with inpatient follow-up of more than six weeks. The time to vivax relapse was significantly longer after mefloquine treatment (median 47 days, range 30-65) than after quinine or quinidine treatment (21 days, 15-36; p<0·0001). All patients remained outside areas of malaria transmission. These findings suggest a very high rate of double infection in Thailand with acute suppression of vivax by falciparum malaria, and warrant evaluation of radical therapy with primaquine in certain patients with acute falciparum malaria.
Sornchai Looareesuwan, Polrat Wilairatana, S Krudsood, Sombat Treeprasertsuk, Pratap Singhasivanon, Valai Bussaratid, W. Chokjindachai, Parnpen Viriyavejakul, K Chalermrut, Douglas S. Walsh, Sir Nicholas White
Udomsak Silachamroon, Srivicha Krudsood, Sombat Treeprasertsuk, Polrat Wilairatana, KOBSIRI CHALEARMRULT, HLA YIN MINT, Pannamas Maneekan, Sir Nicholas White, VICTOR R. GOURDEUK, Gary M. Brittenham, Sornchai Looareesuwan
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