Hept Derivatives: 6-Benzyl-1-ethoxymethyl-5-isopropyluracil (MKC-442)

Masanori Baba; Hlromichi Tanaka; Tadashi Miyasaka; Satoshi Yuasa; Masaru Ubasawa; Richard Walker; De Clercq Erik

doi:10.1080/15257779508012431

Abstract

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Abstract The 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives have been found to be potent and specific inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in vitro. Among the compounds, MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil) has recently been chosen as a candidate for clinical efficacy and safety studies in patients with the acquired immune deficiency syndrome (AIDS).

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