HDL-C AND LDL-C ARE ASSOCIATED WITH BMD IN PREMENOPAUSAL AND ELDERLY WOMEN RESPECTIVELY

Recent studies have explored the association between serum lipids and bone mineral density (BMD). However, the results are inconsistent and studies for premenopausal women are very sparse. For the investigation without confounding effects of menopause, we analyzed the data collected from premenopausal women in early 40s and elderly women aged 70 and older, and comprehensive physiologic markers were included. Our Korean study population was consisted of 3,953 premenopausal women (age range 40~44, mean age 42.3 ± 1.3) and 986 elderly women (70~92, 73.8 ± 3.5). BMDs were measured by dual X-ray absorptiometry at lumbar spine (LS), femoral neck (FN), and total hip (TH). Height, percent body fat, and fasting serum measures of total cholesterol (TC), HDL-C, LDL-C, triglyceride, hsCRP, albumin, glucose, gamma-glutamyltransferase (GGT), estradiol, thyroid-stimulating hormone, and estimated GFR were included in the analyses. Multivariate linear regression models were used to examine relationships between BMD (dependent variable) and other variables. After adjusting for covariates, HDL-C was negatively associated with BMD at LS (β = -0.052, p = 0.004), FN (β = -0.064, p = 0.000), and TH (β = -0.073, p = 0.000) in premenopausal women. In elderly women, LDL-C was negatively associated with BMD at LS (β = -0.104, p = 0.001), FN (β = -0.057, p = 0.068), and TH (β = -0.064, p = 0.042). Our results suggest that serum lipids are inversely correlated with BMD and the pattern is different among young and old women.