GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy

Linda Broer; Aron S. Buchman; Joris Deelen; Daniel S. Evans; Jessica D. Faul; Kathryn L. Lunetta; Paola Sebastiani; Jennifer A. Smith; Albert V. Smith; Toshiko Tanaka; Lei Yu; Alice M. Arnold; Thor Aspelund; Emelia Benjamin; Philip L. De Jager; Gudny Eirkisdottir; Denis A. Evans; Melissa E. Garcia; Albert Hofman; Robert C. Kaplan; Sharon L. R. Kardia; Douglas P. Kiel; Ben A. Oostra; Eric Orwoll; Neeta Parimi; Bruce M. Psaty; Fernando Rivadeneira; Jerome I. Rotter; Sudha Seshadri; Andrew Singleton; Henning Tiemeier; André G. Uitterlinden; Wei Zhao; Stefania Bandinelli; David A. Bennett; Luigi Ferrucci; Vilmundur Guðnason; Tamara B. Harris; David Karasik; Lenore J. Launer; Thomas T. Perls; P. Eline Slagboom; Gregory J. Tranah; David R. Weir; Anne B. Newman; Cornelia M. van Duijn; Joanne M. Murabito

doi:10.1093/gerona/glu166

Abstract

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We did not identify new genome-wide significant associations with longevity and did not replicate earlier findings except for APOE and FOXO3. Our inability to find new associations with survival to ages ≥90 years because longevity represents multiple complex traits with heterogeneous genetic underpinnings, or alternatively, that longevity may be regulated by rare variants that are not captured by standard genome-wide genotyping and imputation of common variants.

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