Graphene-Oxide Based Fluorescent DNA Aptasensor for Liver Cancer Diagnosis and Therapy
Preprint 2021 en
Authors
KM
Ke Ma
WX
Wei Xie
WL
Wei Liu
Abstract
1 min read
Graphene-oxide based fluorescent DNA aptasensors for the <i>in vivo </i>application remain a challenging task. We demonstrate for the first time such a nanomaterial for <i>in vivo</i> diagnosis and therapy of liver tumor with good biocompatibility and high selectivity. This DNA nanomaterial comprising of DNA tetrahedron and aptamers, aggregation-induced emission luminogen (AIEgens) and antitumor drug doxorubicin, is fabricated and attached on GO surface. Additionally, this GO-based fluorescent DNA nanodevice is also constructed by using microfluidic chip for liver tumor cell screening.
Anne-Laure Rérole, Jessica Gobbo, Aurelie De Thonel, E. Schmitt, Jean-Paul Paı̈s de Barros, Arlette Hammann, David Lanneau, Eric Fourmaux, Oleg Deminov, Olivier Micheau, Laurent Lagrost, Pierre Colas, Guido Guido Kroemer, Carmen Garrido
Anne-Laure Rérole, Jessica Gobbo, Aurelie De Thonel, E. Schmitt, Jean-Paul Paı̈s de Barros, Arlette Hammann, David Lanneau, Eric Fourmaux, Oleg Deminov, Olivier Micheau, Laurent Lagrost, Pierre Colas, Guido Guido Kroemer, Carmen Garrido
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