Cross-sectional analysis of randomised controlled trials (RCTs) related articles published in the highest ranked medical journals with an impact factor > 10 (according to Journal Citation Reports published in 2017). We searched PubMed/MEDLINE (from inception to December 31, 2017) for all RCTs related articles (e.g. primary RCTs, secondary analyses and methodology papers) published in high-impact factor medical journals.
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