Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Zachary Steinhart; Zvezdan Pavlovic; Megha Chandrashekhar; Traver Hart; Xiaowei Wang; Xiaoyu Zhang; Mélanie Robitaille; Kevin R. Brown; Sridevi Jaksani; Rene Overmeer; Sylvia F. Boj; Jarrett Adams; James Pan; Hans Clevers; Sachdev S. Sidhu; Jason Moffat; Stéphane Angers

doi:10.1038/nm.4219

Corrigendum2017

Erratum: Corrigendum: Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar, Traver Hart, Xiaowei Wang, Xiaoyu Zhang, Mélanie Robitaille, Kevin R. Brown, Sridevi Jaksani, Rene Overmeer, Sylvia F. Boj, Jarrett Adams, James Pan, Hans Clevers, Sachdev S. Sidhu, Jason Moffat, Stéphane Angers

Article2012

Meta-analysis of genome-wide association studies of single nucleotide polymorphisms in selected genes of the WNT signaling pathway

Thomas Höfer, Nicole Probst‐Hensch, Emmanuelle Bouzigon, Medea Imboden, Paul M Ridker, Adaikalavan Ramasamy, Alexessander Couto Alves, Ivan Curjuric, Joachim Heinrich, Marie Standl, Alexandra Schneider, Regina Hampel, Valérie Siroux, F. Kauffmann, Florence Démenais, Thierry Rochat, David P. Strachan, Deborah Jarvis, Oliver Eickelberg, Mélanie Königshoff, Matthias Wjst

Article2012

Meta-analysis of genome-wide association studies of single nucleotide polymorphisms in selected genes of the WNT signaling pathway

Thomas Höfer, Nicole Probst‐Hensch, Emmanuelle Bouzigon, Medea Imboden, Paul M Ridker, Adaikalavan Ramasamy, Alexessander Couto Alves, Ivan Curjuric, Joachim Heinrich, Marie Standl, Alexandra Schneider, Regina Hampel, Valérie Siroux, F. Kauffmann, Florence Démenais, Thierry Rochat, David P. Strachan, Deborah Jarvis, Oliver Eickelberg, Mélanie Königshoff, Matthias Wjst

Article2025

Meta-analysis of multi-center transcriptomic profiles and machine learning reveal phospholipase Cβ4 as a Wnt/Ca²+ signaling mediator in glioblastoma immunotherapy

Zhaoming Song, Fei Wang, Yangchao Chen, Yifan Guo, Jinfeng Li, Run Huang, Hongyi Ling, Guosheng Cheng, Zhouqing Chen, Zhanchi Zhu, Zhong Lin Wang

Article2025

Preliminary results from a Genome-Wide Association Study of pancreatic neuroendocrine neoplasms identify novel susceptibility loci

Manuel Gentiluomo, Laufey T. Ámundadóttir, Federico Canzian, Samuel O. Antwi, Thor R. Halfdanarson, Markus W. Büchler, Anna Caterina Milanetto, Jun Zhong, Erin E. Carlson, Claudio Luchini, Kari G. Rabe, Francesco Perri, Ann L. Oberg, Péter Hegyi, Rita T. Lawlor, Giuseppe Vanella, Hermann Brenner, Thomas Hank, Claudio Pasquali, Christoph Michalski, Lívia Archibugi, Juozas Kupčinskas,

Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Discussion(0)

Related publications

Erratum: Corrigendum: Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Meta-analysis of genome-wide association studies of single nucleotide polymorphisms in selected genes of the WNT signaling pathway

Meta-analysis of genome-wide association studies of single nucleotide polymorphisms in selected genes of the WNT signaling pathway

Meta-analysis of multi-center transcriptomic profiles and machine learning reveal phospholipase Cβ4 as a Wnt/Ca²+ signaling mediator in glioblastoma immunotherapy

Preliminary results from a Genome-Wide Association Study of pancreatic neuroendocrine neoplasms identify novel susceptibility loci