Genome-Wide Association Study of <scp>l</scp> -Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine

These genome-wide association study support the importance of DDAH1 and MED23/Arg1 in regulating ADMA and l-arginine metabolism, respectively, and identify a novel regulatory renal pathway for SDMA by AGXT2. AGXT2 variants might explain part of the pathogenic link between SDMA, renal function, and outcome. An association between AGXT2 variants and stroke is unclear and warrants further investigation.