Genome-wide association studies of atrial fibrillation: past, present, and future
Article 2011 en
Authors
MS
Moritz F. Sinner
PE
Patrick T. Ellinor
TM
Thomas Meitinger
Abstract
1 min read
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the arrhythmia. Susceptibility loci also have been identified by GWAS for PR interval duration, a quantitative phenotype related to AF. In this review article, we have sought to summarize the latest findings for population-based genetic studies of AF, to highlight ongoing functional studies, and to explore the future directions of genetic research on AF.
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