Genome-Wide Analysis of Cadmium-Induced, Germline Mutations in a Long-Term <i>Daphnia pulex</i> Mutation-Accumulation Experiment

These results provide evidence that cadmium changes regional mutation rates and can influence regional rates by interfering with an epigenetic process in the <i>Daphnia pulex</i> germline. We further suggest these observed cadmium-induced changes to the <i>Daphnia</i> germline mutation rate may be explained by cadmium's inhibition of zinc-containing domains. The cadmium-induced changes to germline mutation rates and spectra we report provide a comprehensive view of the mutagenic perils of cadmium and give insight into its potential impact on human population health. https://doi.org/10.1289/EHP8932.