Genetic approaches to the study of Toll-like receptor function

Osamu Takeuchi; Akira Shizuo

doi:10.1016/s1286-4579(02)01615-5

Genetic approaches to the study of Toll-like receptor function

Microbes and Infection 4(9): 887-895

Article 2002 English

Abstract

1 min read

The Toll-like receptor (TLR) family plays a role in sensing invading pathogens. Ten members have been reported to date, seven of which were found to recognize discrete bacterial components. Mouse models lacking each TLR and its signaling molecule are useful tools for the analysis of the innate immune system.

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